Induced pluripotent stem cells-derived cardiomyocytes(iPSC-CMs) have the electrophysiological characteristics of human cardiomyocytes and can truly simulate human cardiomyocytes. Because the hERG detection assayis limited to predict thecardiotoxicity of drugs, iPSC-CMs becomean ideal model for studying cardiotoxicity and drug safety evaluation. E-4031 is the methanesulfonanilide class IIIantiarrhythmic drug, which can selectively block hERG K+ channels and prolong the action potential duration. The EPhys team in ICE Bioscience InC. has gained years of experience to validate patch clamp methods for action potentials (AP) in iPSC-CMsand related ion channels for drug screening.
