Polyclonal Antibody

CATALOG #: 3045-100
AMOUNT: 100 μg
LOT #: ________________
FORMULATION:
100 μg (0.5 mg/ml) affinity purified, rabbit anti-TRAIL polyclonal antibody in phosphate
buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide.
SPECIES REACTIVITY: Human
STORAGE CONDITIONS:
Store at -20°C. For long term storage, aliquot and freeze at -70°C. Avoid repeated
freeze/defrost cycles.
BACKGROUND DESCRIPTION:
TRAIL (TNF-related apoptosis-inducing ligand), a member of the TNF ligand family, is a type
II membrane protein and expressed in a variety of human tissues. Two death domains
containing receptors DR4 and DR5 have been identified as the receptors for TRAIL and two
decoy receptors designated DcR1 and DcR2 inhibit TRAIL function. The multiple receptors
suggest a complex role for regulation of signaling by the cytokine. TRAIL induces apoptosis
and NF-kB activation in many tissues and cells.
SPECIFICITY:
The antibody detects a 32 kDa protein, corresponding to the apparent molecular weight of
TRAIL on SDS-PAGE immunoblots, in human cell lines.
APPLICATION AND USAGE:
The antibody can be used for Western blot analysis (0.5-1 μg/ml), ELISA (2-3 μg/ml) and
neutralization (5-10 μg/ml). However, the optimal conditions should be determined
individually.
FOR RESEARCH USE ONLY! Not to be used on humans.
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