FITC标记的肢体畸形相关蛋白FMN1抗体
产品名称： FITC标记的肢体畸形相关蛋白FMN1抗体
英文名称： Anti-FMN1/FITC
产品编号： HZ-13185R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-FMN1/FITC Conjugated antibody
| FITC标记的肢体畸形相关蛋白FMN1抗体 |
| 英文名称 | Anti-FMN1/FITC |
| 中文名称 | FITC标记的肢体畸形相关蛋白FMN1抗体 |
| 别 名 | FMN; Formin 1; Formin1; Formin-1; LD; Limb deformity protein homolog; FMN1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 157kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FMN1/Formin 1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The temporal genetic hierarchy influencing normal limb development can deregulate and mediate mammalian developmental syndromes. In mice, the limb deformity (ld) locus influences normal limb development and gives rise to alternative mRNAs that can translate into a family of proteins known as formins. Formins play a crucial role in cytoskeletal reorganization by influencing Actin filament assembly. Formins co-localize with the actin cytoskeleton and can translocate into the cell cytosol and into the nucleus in an HGF-dependent manner. Vertebrate nuclear formins can control polarizing activity in limb buds through establishment of a Sonic hedgehog/FGF-4 feedback loop. Deficiency mutations at the mammalian ld locus lead to profound developmental defects in limb and kidney formation. The human Formin 1 and 2 genes map to chromosome 15q13.3 and 1q43, respectively. Function: FMN1 plays a role in the formation of adherens junction and the polymerization of linear actin cables. Interacts with alpha-catenin and may interact with tubulin. Subunit: Interacts with alpha-catenin and may interact with tubulin (By similarity). Subcellular Location: Nucleus. Cytoplasm. Cell junction, adherens junction; Peripheral membrane protein; Cytoplasmic side. Post-translational modifications: Phosphorylated on serine and possibly threonine residues (By similarity). Similarity: Belongs to the formin homology family. Cappuccino subfamily. Contains 1 FH1 (formin homology 1) domain. Contains 1 FH2 (formin homology 2) domain. Database links: Entrez Gene: 342184 Human Entrez Gene: 14260 Mouse Omim: 136535 Human SwissProt: Q68DA7 Human SwissProt: Q05860 Mouse Unigene: 657649 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
影响正常肢体发育的时间遗传层次可以解除和调解哺乳动物发育综合征。在小鼠中，肢体畸形（ld）位点影响正常肢体发育，并产生可翻译成称为formins的蛋白家族的替代mRNA。通过影响肌动蛋白丝组装，形成素在细胞骨架重组中起着至关重要的作用。Formins与肌动蛋白细胞骨架共存，可以以HGF依赖的方式转运到细胞胞浆和核中。脊椎动物核型可以通过建立超音速刺猬/FGF-4反馈回路来控制肢芽的极化活动。哺乳动物LD位点的缺失突变导致肢体和肾脏形成的严重发育缺陷。人Falm 1和2基因分别定位于染色体15q133和1q43。