ERO1L 抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
ERO1L 抗体

ERO1L 抗体

商家询价

产品名称： ERO1L 抗体

英文名称： ERO1L Antibody

产品编号： XY12007-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 ERO1L 抗体

Applications
In-house applications ELISA, IHC, WB, FC, IP     Application not tested? Please see our Guarantee.
Published applications WB Publications 1 citations –view here
Species specificity Human,Mouse,Rat; other species not tested.
Published Species Mouse
Images
Prev12NextView more validation data
  • 12007-1-AP;mouse ovary tissuemouse ovary tissue were subjected to SDS PAGE followed by western blot with 12007-1-AP(ERO1L antibody) at dilution of 1:100
  • 12007-1-AP;Pancreas cancerImmunohistochemical of paraffin-embedded human pancreas cancer using 12007-1-AP(ERO1L antibody) at dilution of 1:50 (under 10x lens)
  • 12007-1-AP;L02 cellsIP Result of anti-ERO1L (IP:12007-1-AP, 4ug; Detection:12007-1-AP 1:300) with L02 cells lysate 1400ug.
  • 12007-1-AP;HeLa cells1X10^6 HeLa cells were stained with 0.2ug ERO1L antibody (12007-1-AP, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1000.
Positive WB detected in Mouse ovary tissue, A431 cells
Positive IP detected in L02 cells
Positive IHC detected in Human pancreas cancer tissue
Positive FC detected in HeLa cells
Recommended dilution WB : 1:200-1:1000
IP : 1:200-1:1000
IHC : 1:20-1:200
 ERO1L 抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen ERO1L fusion protein ag2620 Full name ERO1-like (S. cerevisiae)
Calculated molecular
weight		 468aa,54 kDa Observed molecular 
weight		 54 kDa
GenBank accession 
number		 BC008674 Gene ID (NCBI) 30001
Gene symbol ERO1L Synonyms ERO1 alpha, ERO1 L, ERO1 L alpha, ERO1 like (S. cerevisiae), ERO1 like protein alpha, ERO1L, Oxidoreductin 1 L alpha
Background ERO1L 抗体

ERO1L, also named as ERO1-alpha, is an essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. It acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. It does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Glutathione may be required to regulate its activity in the endoplasmic reticulum. It may be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress. It is required for the folding of immunoglobulin proteins. Responsible for the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. This antibody has no cross reaction to ERO1L. ERO1L 抗体

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