FITC标记的脊髓性肌萎缩症蛋白SMA抗体
产品名称： FITC标记的脊髓性肌萎缩症蛋白SMA抗体
英文名称： Anti-Gemin 3/FITC
产品编号： HZ-11563R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Gemin 3/FITC Conjugated antibody
FITC标记的脊髓性肌萎缩症蛋白SMA抗体
| 产品编号 | bs-11563R-FITC |
| 英文名称 | Anti-Gemin 3/FITC |
| 中文名称 | FITC标记的脊髓性肌萎缩症蛋白SMA抗体 |
| 别 名 | Gemin3; Component of gems 3; DDX 20; DDX20; DDX20_HUMAN; DEAD (Asp Glu Ala Asp) box polypeptide 20; DEAD (Asp-Glu-Ala-Asp) box polypeptide 20; DEAD box protein 20; DEAD box protein DP 103; DEAD box protein DP103; DEAD-box protein DP103; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 20 103kD; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 20; DEAD/H BOX 20; DKFZP434H052; DP 103; DP103; Gemin-3; Gemin3; Probable ATP dependent RNA helicase DDX20; Probable ATP-dependent RNA helicase DDX20; SMN interacting protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 神经生物学 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 92kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Gemin 3 (101-200aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008]. Function: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. Subunit: Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts directly with SMN1 and with several spliceosomal snRNP core Sm proteins, including SNUPN, SNRPB, SNRPD2 and SNRPD3. Interacts with PPP4R2. Interacts with EBV EBNA2 and EBNA3C. Interacts with FOXL2. [SUBCELLULAR LOCATION] Cytoplasm. Nucleus, gem. Note=Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems). Subcellular Location: Cytoplasm. Nucleus Tissue Specificity: Ubiquitous. Similarity: Belongs to the DEAD box helicase family. DDX20 subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Database links: Entrez Gene: 11218 Human Entrez Gene: 53975 Mouse Omim: 606168 Human SwissProt: Q9UHI6 Human SwissProt: Q9JJY4 Mouse Unigene: 591405 Human Unigene: 272826 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
死盒蛋白，其特征在于保守的基序ASP Glu ALA-ASP（死亡），是假定的RNA解旋酶。它们涉及许多细胞过程，涉及RNA二级结构的改变，如翻译起始、核和线粒体剪接、核糖体和剪接体组装。根据它们的分布模式，该家族的一些成员被认为参与胚胎发生、精子发生和细胞生长和分裂。该基因编码一个死盒蛋白，它具有ATPase活性，是运动神经元（SMN）复合物存活的一个组成部分。这种蛋白直接与SMN，脊髓肌萎缩基因产物相互作用，并可能在RNPs的SMN复合物的功能中发挥催化作用。