Recombinant Murine IGF-1

Maspin is a non-inhibitory member of the serpin superfamily, a group of 40-60 kDa serine protease inhibitors. Maspin was discovered in 1994 and has been identified in prostate, thymus, testis, intestine, tongue, and lung. Recently Maspin received a great deal of attention due to its potential apoptotic role in cancers. Maspin expression predicts a better prognosis for several types of carcinomas including breast, prostate, colon, and oral squamus cell carcinoma. The level of Maspin is also inversely correlated to VEGF-A, an angiogenic factor. Researchers found that Maspin may play its apoptotic role as an endogenous inhibitor of histone deacetylase I (HDAC I). Therefore, Maspin is a potential personalized marker of Non-Small Cell Lung Carcinoma (NSCLC).

Recombinant human Maspin (rhMaspin) produced in E. coli is a single non-glycosylated polypeptide chain containing 375 amino acids. rhMaspin has a molecular mass of 42.1 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.

Recombinant Murine IGF-1

steopontin is a glycoprotein that was first identified in osteoblasts and is involved in bone remodeling，immune functions in fibroblasts，macrophages，and lymphocytes during inflammation and wound healing。 SPP1 binds tightly to hydroxyapatite。 SPP1 forms an integral part of the mineralized matrix。 SPP1 is vital to cell-matrix interaction。

Secreted Phosphoprotein-1 protects against cardiac ischemia-reperfusion injury via late preconditioning。 Expression of both Ostepontin and CD44 in hepatocellular carcinoma is linked with advanced tumor stage and contributes to prognosis information。 SPP1 is the most over-expressed gene in intrahepatic cholangiocarcinoma。 Secreted Phosphoprotein-1 overexpression is related with interstitial lung diseases。

Recombinant Murine IGF-1