This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5 untranslated region have been found for this gene.[provided by RefSeq, Jan 2010]Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. *   http://www.creative-diagnostics.com/Anti-CLDN2-PAb-191897-147.htm